The Report Card on Growth Differentiation Factor 15
نویسندگان
چکیده
منابع مشابه
The report card on growth differentiation factor 15: consistent marks but not yet ready for promotion.
In the present era that includes multiple potential treatment strategies for patients with acute and chronic coronary artery disease (CAD), a primary goal is to match the intensity of therapy with an individual patient’s risk for an adverse outcome. To accomplish this goal, improved risk stratification algorithms are needed. Among the potential strategies to improve risk assessment, measurement...
متن کاملGDF 15 ( growth differentiation factor 15 )
The premature GDF/PDF/MIC-1 protein consists of 308 amino acids that contain a 29 amino acid signal peptide, a 167 amino acid propeptide, and a 112 amino acid mature protein. The mature protein is secreted as a homodimer linked by disulfide bonds and is released from the propeptide following intracellular cleavage at RXXR furine-like cleavage site. The mature peptide of GDF-1/MIC-1 contains two...
متن کاملGrowth differentiation factor 15: a canary in a coal mine?
It has been 50 years since Dr. William B. Kannel coined the term “factors of risk” in relation to cardiovascular disease (1). Since then, clinical risk assessment, including the use of circulating biomarkers, has become an integral part of medical practice. The current era of genomics, proteomics, and metabolomics is projected to lead to the discovery of an immense number of novel candidate bio...
متن کاملRegulation of growth differentiation factor 15 expression by intracellular iron.
Growth differentiation factor 15 (GDF15) is a divergent member of the transforming growth factor-beta superfamily and has been identified in different contexts as a hypoxia-inducible gene product and as a molecule involved in hepcidin regulation. The biology of iron and oxygen is closely related, and known regulatory pathways involving hypoxia-inducible factor (HIF) and iron-regulatory proteins...
متن کاملGrowth Differentiation Factor 15 Predicts Chronic Liver Disease Severity
Background/Aims Growth differentiation factor 15 (GDF-15) belongs to the transforming growth factor-β superfamily. GDF-15 is emerging as a biomarker for several diseases. The aim of this study was to determine the clinical performances of GDF-15 for the prediction of liver fibrosis and severity in chronic liver disease. Methods The serum GDF-15 levels were examined via enzyme immunoassay in 1...
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ژورنال
عنوان ژورنال: Circulation: Cardiovascular Genetics
سال: 2009
ISSN: 1942-325X,1942-3268
DOI: 10.1161/circgenetics.109.874511